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Babies of a Specified Sex
Man has long desired to obtain progeny, both of his own and of his domestic animals, of a specified sex for various reasons. Efforts to produce zygotes and embryos of the specified sex have been remarkably successful, and some companies have emerged to fulfil this objective.

The general procedure for achieving this objective is briefly described in simple terms. In case of humans, males produces two kinds of sperms:

(i) 50% of the sperms contain X chromosome and produce female progeny on fertilization, while.

(ii) the rest 50% are Y chromosome containing and give rise to male embryos.

The semen of prospective father is collected and processed according to a specific procedure to separate Y-carrying sperms from the X-carrying ones. In case a couple desire to have a male baby, the Y chromosome containing fraction of semen is used for artificial insemination, while the X chromosome containing fraction will be used in case of those desiring a female baby.

The procedure for collecting X chromosome containing sperms uses a sephadex gel column through which the semen is passed. Since Y chromosome containing sperms are lighter than those having X chromosome, they are held up in the column for a much longer period than the latter.

Therefore, the initial fraction of semen collected from the column contains X chromosome bearing sperms. Separation of Y chromosome containing sperms, on the other hand, is based on quinacrine staining. The success in producing male babies using this procedure is reported to be close to 90%, and so far hundreds of male children have been produced.

The techniques for producing babies of a specified sex raise some disturbing sociological and even ethical questions. One such question relates to the male: female ratio in the population. These questions have to be addressed to by each society in an effort to arrive at suitable answers.