Heli Cell Vessels - These vessels are packed with polystyrene ribbons (3 mm x 5-10 mm x 100 µm) that are twisted in helical shape. The medium is pumped through the vessel, the helical shape of ribbons ensuring good circulation; the cells adhere to the ribbon surfaces.

All the culture vessels, in addition to the increased surface area due to the vessel design, allow further scaling up by the use of multiple units of the vessels. In contrast, the following three culture systems allow scaling up in a single unit by increasing the vessel volume. In addition, they make the monolayer culture system considerably similar to suspension cultures.