Biosafety During Industrial Production, Microbial Products, Microbes, Downstream Processes, Cell Debris

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	Biosafety During Industrial Production - Many of the processes of manufacture have the potential to generate biohazards. Therefore, it is not surprising that several noninfectious illnesses are associated with biotechnology industrial products/processes. Inhalation appears to be the most significant mode of entry of microbes or microbial products into the body, while entry by ingestion or skin contact can readily be prevented by good operating practice.
Most reported health problems are associated with downstream processes, and the risk of allergic reaction is the greatest after the product is more concentrated. During extraction of intracellular enzymes, the greatest risk is posed by the processes of handling the large quantities of cell debris. An effective monitoring strategy should involve environmental assessment of emissions at all stages of a manufacturing process, and a critical assessment of the biosafety performance of process equipments; in addition, it should maintain adequate surveillance of worker health.