The DBT implements the research and development experiments utilizing GMOs and recombinant DNA products, while MOEF implements the large scale commercial use of these. the sailent features of these guidelines and Regulations are as follows.

1. Every organisation involved in research and development using recombinant DNA technology is required to set up an institutional biosafety committee (IBC), which has a DBT nominee, IBC is the nodal point for interaction of the organization wit the government.

2. The DBT has a review commitee for genetic manipulation (RCGM), which has all the approvals of on going projects on GMOs and several other issues realted to recominant DNA research and development.

6. experiments  with microorganisms, plants and animals are grouped into the following categories :

(i) Exempt category ( for self cloning experiments)

(ii) category requiring intimation on initiation to competent authority ( experiments involving nonpathogenic DNA vector systems)

(iii) category requiring review and approval by the competent authority ( cloning of genes for toxins , antibiotic resistance , etc)

7. Four different biosafety levels are recognised and containment fecilities for each level are recommended for necessary safeguards

8. Physical Containment envisages to limits the spread of dangerous micororganisms by

(i) Good laboratory practices

(ii)safety equipment and

(iii) laboratory design and facilities

9.Biological containment consists of the use of vector and hosts in such a way so that it

(i) can limit the infectivity of vector to specific hosts, and

(ii) control host vector survival in the environment