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Objectives of Safety Guidelines - The National Institute of Health (NIH, USA) has developed guidelines for recombinant DNA research with a view to specify the practices for constructing and handling

(i) recombinant DNA molecules, and

(ii) organisms and viruses containing recombinant DNA molecules. These guidelines require approval and clearance of any recombinant DNA experiment that requires such approval/clearance from NIH or another Federal agency.

All experiments involving the deliberate transfer of recombinant DNA, or DNA or RNA- derived from recombinant DNA into human subjects can not be initiated without submission of the required information to NIH and other specified agencies.

Cartagena Protocol on Biosafety to the Convention on Biological Diversity has been designed to cover the transboundary movement, trails it, handling and use of all living modified organisms that may have adverse effects on the conservation and sustainable use of biological diversity, taking into account risks to human health.

The ultimate objective of guidelines that regulate research and development activities using recombinant DNA technology should be to minimise risk from such activities and, at the, same time, encourage these activities.