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Comparison Between Enzymes and Nonbiological Catalysts

Feature

Enzymes

Nonbiological catalysts

Specificity Highly specific; binding to substrate may be less specific but the catalyzed reaction is highly specific Nonspecific

Rate of reaction

Enhanced by a factor of 103-106 Enhancement only a fraction of that by enzymes

Regulation

Enzymes are subject to a variety of regulations, which increase/ decrease reaction rate They are not subject to such regulations

Saturation

Enzymes have a maximum reaction rate with respect to substrate concentration Most catalysts do not show sub­strate staturation
Chemical nature Enzymes are proteins (RNA with enzymatic action is called ribozyme) Metal and nonmetal inorganic molecules
Temperature, pressure and pH Mild, biologically compatible

Often high temperature and high pressure

Side reactions Do not occur Occur