Immobilization of Enzymes by Adsorption - In case of adsorption, the enzyme molecules adhere to the surface of carrier matrix due to a combination of hydrophobic effects and the formation of several salt links per enzyme molecule.

Some of the commonly used matrices are ion exchange matrices, porous carbon, clays, hydrous metal oxides, glasses, and polymeric aromatic resins. Ion exchange matrices are costly, but they can be readily regenerated by a simple operation, e.g., washing off the adsorbed enzyme with a concentrated salt solution.