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Bacteria - A large number of bacterial species have been evaluated for SCP production
(i) using a wide variety of substrates;
(ii) some of these have been used for production at commercial scales, e.g., Methylophilus methylotrophus using methanol. SCP has very high crude protein (over 80%) of good amino acid composition, although in some cases a small deficit of sulphur-containing amino acids may be encountered.

The disadvantages of using bacteria for SCP production are,

(i) highnucleic acid, especially, RNA content (Ca. 20%), which must be reduced,
(ii) sterility must be maintained during the production process since pH of cultures is kept between 5 and 7,
(iii) risk of contamination by pathogenic bacteria is considerable,
(iv) recovery of cells is problematic, and
(v) carefull evaluation for endotoxin production is essential particularly when Gram negative bacteria are used.