Triple
stranded
nucleotide
chains
were
first
created
in
1957
by
Alexander
Rich,
David
Daves
and
Gary
Felsenfeld,
while
they
were
creating
artificial
nucleic
acids.
At
that
time,
triple-stranded
DNA
seemed
like
a
laboratory
curiosity.
Now
it
seems
of
interest,
because
it
may
have
valuable
uses,
both
experimentally
and
clinically.
Triplex
DNA
is
generated
by
binding
a
known
single
stranded
DNA
because
single
strand
of
DNA
is
capable
of
recognizing
a
relatively
long
sequence
of
the
double
stranded
DNA
in
a
chromosome
Thus
it
is
possible
to
selectively
locate
a
particular
gene
loci
or
sequence.
The
second
use
of
triplex
DNA
is
to
cut
DNA
at
a
specific
place
by
adding
a
cleaving
compound
to
both
ends
of
the
third
strand
of
DNA.
However,
it
seems
to
have
good
potential
for
therapeutic
use
and
to
help
in
studying
and
mapping
the
human
genome.
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