Protein Interactions, Modulating Protein, RNA Splicing, Mapping Methods, Bioinformatics Tools

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	Protein Interactions- At the most fundamental level, gene function reflects the behaviour of proteins encoded by them. This behaviour may be seen as a series of interactions among various proteins, and between proteins and other molecules. For example, the drugs used to treat diseases act by modulating protein interactions in a beneficial manner. The logic of studying protein interactions is as follows. Suppose, the function of protein A is unknown. Protein A is discovered to interact with proteins B and C, which participate in RNA splicing.
This interaction would indicate the protein A to be involved in RNA splicing. Protein interactions are studied using high throughput techniques. A number of library based protein interaction mapping methods allow hundreds or thousands of proteins to be screened at a time. These interactions may be assayed in vitro or in vivo. Protein interaction data from various sources are assimilated in databases. Several bioinformatics tools have been developed to extract information from such databases. A major challenge is to find a simple way to present protein interaction data in readily accessible and understable format.