Radiolabelled
Monoclonal
Antibodies -
Radiolabelled
monoclonal
antibodies
have
also
been
developed for
delivery
of
a
cytotoxic
effector
to
target
cells
and
for
radioimaging.
For
therapy,
one
advantage
of
using
radiolabelled
antibodies,
is
that
they
can
kill
cells
from
a
distance
and
thus
can
also
kill
cells
adjacent
to
antigen
expressing
cells.
Further,
the
radiolabelled
antibody
need
not
be
internalized
to
kill
the
tumour
cells.
For
the
purpose
both β emitting
.(e.g
731
I)
and
alpha
emitting
radionuclides.
have
been
used
for
patients
with
hepatoma,
HTL
V-1
(human
T
cell
leukemia/lymphoma
virus
-1),
ATL
(adult
T-cell
leukemia),
a
variety
of
allografts,
etc.



