For instance, in an experiment, mouse human hybrid cell line CHI-16, containing human chromosome 16 as the only human component, was used to construct a cosmid library with DNA fragments of approximately 40 kilobase pairs in length.
From this library, cosmids containing chromosome 16 specific human DNA inserts could be selected through hybridization with 32P-labeled human genomic DNA. These cosmid probes when used for mapping would give a cytogenetic map for chromosome 16 and so on.
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