Altering Gene Functions by Mis sense Mutations,Mutant Phenotype,Conservative,Protein

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	Altering Gene Functions by Mis sense Mutations - Mutations occurring at the first or second nucleotide position of a codon result in mis sense mutation. This alteration will create a new amino acid instead of an old amino acid. A mis sense mutation gives rise to a polypeptide with a single amino acid change. Whether or not this causes a mutant phenotype depends on the precise role of the mutated amino acid in the structure and/or function of the protein.
Most proteins can tolerate some change in their amino acid sequence, but mutations that alter an amino acid essential for structure or function will inactivate the protein and lead to a mutant phenotype. Mis sense mutations are further classified as conservative (or) radical depending upon the type of amino acid substituted.