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Applications of Mutations - Mutations are invaluable to the process of evolution since they provide the raw material required for its occurrence. Even though most mutations make the organism less efficient and are thus disadvantageous, the possibility of developing new traits through induced mutations has intrigued many plant breeders.

Many plant strains were improved for higher yield, higher resistance against disease and pest by using mutations. One application of induced mutations comes from the concentrated efforts to improve the yield of penicillin by the mold penicillium. When penicillin was first discovered, the yield was low and production was seriously limited.

Then millions of spores were irradiated and selected for higher yields. Such mutants who produce penicillin more than the average have proven invaluable in the commercial production of this important antibiotic.

Mutations have been used extensively to elucidate the pathways by which biological processes occur. Metabolisms occur via sequences of enzyme catalysed reactions. By isolating and studying mutations in the genes coding for the enzyme involved, the sequence of steps in a pathway can often be determined.

Morphogenesis frequently involves the sequential addition of proteins in the formation of specific 3-D Structures. Again, the sequence of protein additions can often be determined by isolating and studying mutant organisms with mutations in the genes coding for the proteins involved.

 

 

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