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Gene Inversion - Inversion is a phenomenon in which a portion of a gene or a group of genes which have been cut out, turn through an angle of 1800 and get reattached in reverse order. Bridges first discovered inversion in 1923.

In inversion the gene sequence in an inverted segment is exactly the opposite of that in its normal homologous (non-inverted) segment.In case of an inversion, there is no net loss or gain of genetic material and thus a heterozygous condition is perfectly alright, but linkage relationships change.

Inversion will affect the amino acid sequence of polypeptide encoded by that gene, and thus has some genetic effect. Inversions are grouped into two groups depending upon the presence or absence of centromere within the inverted segment.