Batch Bioreactors - In such bioreactors, the medium and inoculum are loaded in the beginning and the cells are allowed to grow. There is no addition/replacement of medium, and the entire cell mass is harvested at the end of incubation period.

The characteristic features of such bioreactor systems are as follows:
(i) continuous depletion of medium,
(ii) accumulation of cellular wastes,
(iii) alterations in growth rate and
(iv) continuous change in the composition of cells.
The spin filter bioreactor can be used as a batch bioreactor by closing the inlet for medium and the outlets for medium/medium plus cells.