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Biochemicals from cultured Plant Cells - Cultured plant cells are known to produce biochemicals of interest since 1950’s, but initially the yields were very low. Refined culture systems have improved the biochemical yields considerably, an over half a dozen cell cultures produce 2 g/l or more Of the biochemical. Shikonin (a naphthoquinone) is produced on a commercial scale from cell cultures of Lithospermum erythrorhizon, while berberine (an alkaloid) is obtained from Coptis japonica cell cultures. Interestingly, Ginseng tissues produced in vitro are used as additives in tonic drinks, wines, soups, herbal liquours, etc.

The biochemicals obtained from plant cell cultures are comparable to those derived from intact plants in their chemical, biochemical and biological properties. In addition, cultured cells of many plant species produce novel biochemicals, which have so far not been detected in whole plants.

For example, cell suspension cultures of Rauwolfia serpentina have been shown to produce 4 highly polar alkaloids, which are novel glucosides of ajmaline and its derivatives.
Biochemical yields from cultured plant cells can be improved by increasing
(1) cell biomass yield per unit volume of culture and
(2) biochemical content of the cell biomass.
Increased biochemical yields reduce production costs. Therefore, they are critical to the commercialization of the process since the break-even price for a biochemical is estimated as $ 1,500/kg.