Enzymatic Disaggregation - Although dissociated cells can also be obtained by the primary explant technique to be discussed in the next chapter, mechanical or enzymatic disaggregation gives a much higher yield of representative cells in a short duration. Further, the embryonic tissue disperses more readily and gives higher yield than the newly born or adult, since in the latter case there are fewer undifferentiated cells, more fibrous connective tissue and extracellular matrix.