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Drug Designing - Drug designing is another area of biotechnology research, which is being actively pursued. Several approaches are being used for this purpose and some of them will be briefly described in this section to give an elementary idea about this important and fascinating area of research.
However, all these approaches are based on an exercise where we first acquire knowledge about active site that needs to be attacked by the drug and then utilize this information to design a drug that will not only bind to the chosen site but will also possess all other properties required of a drug.
Therefore, drug designing will involve atleast three steps:
(i) Knowledge will have to be acquired about the site structure, upto the level of atomic resolutions, so that the accessible surface, which needs to be attacked, is known;

(ii) A ligand will have to be designed that will fit the binding site; for this purpose the steric outline of the ligand should be complementary to the site and, therefore, these complementary features will have to be built in the ligand at appropriate positions. This should result in the maximum interactions between atoms of the ligand and the site, and is mainly achieved with the help of computer aided methods.

(iii) Once the ligand is designed to fit the binding site, ligand needs to be modified to have pharmacological and toxicological properties, while maintaining its affinity for the binding site. This and the above step (ii) will require three dimensional constructions. Computers have provided methods which will allow automated site directed drug designing.