Antibiotic Resistance Genes Found in R-Plasmids their Proteins -
| Antibiotic (gene conferring resistance) |
Protein produced by the gene |
Mechanism of resistance |
| Ampicillin (amp) |
Penicillinase or β-lactamase |
Hydrolysis of C-N bond in β-lactam ring |
| Kanamycin (kan) |
Kanamycin acetyltransferase* |
N-acetylation of the antibiotic |
| Neomycin (nea) |
Aminogycoside phosphotransferase* |
O-phosphorylation of the antibiotic |
| Streptomycin (str) |
Streptomycin phosphotransferase |
Phosphorylation of -OH on the antibiotic |
| |
Streptomycin adenylate synthetase |
Adenylation of the -OH on the antibiotic |
* The antibiotics kanamycin and neomycin are related; hence nea product also inactivates kanamycin, and kan product inactivates neomycin as well.
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