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Nomenclature of Restriction Endonucleases - The nomenclature of restriction endonucleases follows a general pattern.
(1) The first letter of the name of genus in which a given enzyme is first discovered is written in capital.

(2) This is followed by the first two letters of species name of the organism. These three letters are generally written in italics, e.g., Eco from Escherichia coli, Hin from Haemophilus influenzae, etc.

(3) Strain or type identification is depicted next in Roman. e.g., Ecok;

(4) When an organism produces more than one enzyme, they are identified by sequential Roman numerals, e.g., the different enzymes produced by H. influenzae strain Rd are named Hind II, Hind III, etc.