Chromatin Remodelling,Transcription Factors,Nucleosomes,RNA Polymerase,Promoter

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	Chromatin Remodelling - For transcription to take place in eukaryotes, the DNA must be available for the pre initiation complex to form, with its RNA polymerase and general transcription factors. It appears that DNA wrapped around nucleosomes is often not accessible for the formation of the pre initiation complex, but is available for recognition by transcription activating proteins, (specific transcription factors).
One model of initiation of transcription by genes whose promoters are wrapped around nucleosomes is for specific transcription factors to recruit chromatin remodelling protein, e.g. histones, acetyl transferase, ATP dependent chromatin remodelling proteins. Thus, the presence of one or more specific transcription by recruiting chromatin remodelling proteins allows the RNA polymerase access to the promoter