| Gene Transferred |
Objective |
Achievements |
Remarks |
Cattle, goat, sheep and swine
Human genes: α1-anti- Gene fanning trypsin, tissue plasminogen activator, blood clotting factor IX, and protein C |
Gene Farming |
Genes expressed in mammary tissue; proteins secreted in milk in functional form |
Experimental stages |
Sheep
Bacterial genes cysE and cysM (genes concerned with cysteine biosynthesis)
|
Improved wool production/quality |
Genes expressed in transgenic animals |
|
| Mice and Swine Human haemoglobin and specific circulating immunoglobulins (antibodies) |
Proteins from blood serum for blood transfusion and disease diagnosis |
Genes expressed; proteins released in blood serum |
Experimental stages |
| Swine and Sheep Human growth hormone |
Increased and desirable body growth |
Improve body weight gain, feed efficiency, etc. |
Joint pathology, skeletal defects, ulcers, etc. |
Rabbits
Human genes: Interleukin 2, growth hormone, tissue plasminogen activator, etc. Bovine gene: α -Lactoglobulin |
Molecular farming or gene farming |
Recombinant proteins harvested from milk |
Experimental stage |
Fish
Salmon or rainbow trout growth hormone Anti-freeze protein gene, α-globin gene, etc. |
Increased body growth Variable |
Up to 60% increase in size Genes expressed in transgenics |
Growth improved by selection. Transgenes are stably inherited. |
