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Transgenic Animals - A transgenic animal contains in its genome, a gene or genes introduced by one or the other technique of transfection. The gene introduced by transfection is called transgene. In animals, transfection specifies the introduction of a DNA segment, either naked or integrated into a vector, into an animal cell.

It may be pointed out that the same phenomenon is known as transformation in all other organisms. However, in case of animals, transformation has long been used to describe the change of normal, i.e., nontumourous, cells in culture to tumour like cells. Therefore, it became necessary to use the term transfection to avoid confusion.

Transfection may be transient or permanent (stable). In transient transfection, the introduced gene(s) is(are) gradually lost from the daughter cells of transfected cells. But in case of stable transfection, the introduced gene(s) is(are) retained and expressed in all the cells derived from the transfected cells.

Since most of the animal vectors are unstable, i.e., are gradually lost, in the extrachromosomal state, stable transfections are ordinarily due to the intergration of introduced gene(s) into the cell genome.