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Mechanism of Action of Different Herbicides

Active principle of herbicide Inhibited pathway Target product Use Basis of resistance
I.Amino acid biosynthesis inhibitors
1.Glyphosate (Roundup) Aromatic amino acid biosynthsis EPSPS Broad spectrum

Overexpression of EPSPS gene; bacterial aroA gene

2.Sulphonylurea and Imidazolinones Branched chain amino acids ALS Selected crops Mutant ALS gene
3.Phosphinothricin (Basta) Glutamine biosynthesis GS Broad spectrum Gene amplification, bar gene: detoxification
II. Photosynthesis inhibitors
4. Atrazine (Lasso) Photosystem II QB (32 kDa protein) Selected crops Mutant PsbA gene, GST gent; detoxification
5. Bromoxynil (Buctril) Photosynthesis -- Selected crops bxn gene; detoxification